by Prasad Busarla SV, Sayed S, Nazarian RM, Gimbel DC, Moloo Z, Sohani AR on
Kaposi sarcoma in association with molluscum contagiosum: an uncommon diagnosis in a single biopsy and potential diagnostic pitfall.
Am J Dermatopathol. 2012 Feb;34(1):e7-9
Authors: Prasad Busarla SV, Sayed S, Nazarian RM, Gimbel DC, Moloo Z, Sohani AR
Abstract
Molluscum contagiosum is a cutaneous poxviral infection that is rarely associated with other skin diseases, such as cutaneous neoplasms. Such associations are likely to be coincidental, except in immunocompromised patients. Kaposi sarcoma, an angioproliferative neoplasm derived from lymphatic endothelium, is mediated by human herpes virus-8 infection and occurs with increased frequency in immunocompromised individuals. We report an unusual case of molluscum contagiosum with underlying cutaneous Kaposi sarcoma diagnosed in a single skin biopsy of a human immunodeficiency virus-positive patient. Our case highlights the importance of adequate sampling to avoid missing secondary diagnoses in histopathologic sections and alerts pathologists and dermatologists to the possibility of coinfection in high-risk patients by 2 virally-mediated skin conditions.
PMID: 22262366 [PubMed - indexed for MEDLINE]
by Georgala S, Katoulis AC, Kanelleas A, Befon A, Georgala C on
Letter: Human papilloma virus and molluscum contagiosum lesions related to infliximab therapy for psoriasis: A case series.
Dermatol Online J. 2012;18(4):9
Authors: Georgala S, Katoulis AC, Kanelleas A, Befon A, Georgala C
Abstract
INTRODUCTION: Biological therapy for psoriasis exerts its action via an immunomodulatory and eventually immunosuppressive mode. Immunosuppression is linked to HPV flares. Our purpose is to investigate a possible relationship between infliximab therapy for psoriasis and human papilloma virus and molluscum (HPV/MC) infections.
METHODS: We report a case series of three patients with psoriasis on infliximab, who developed HPV/MC lesions following their treatment.
RESULTS: Our patients developed HPV/MC lesions within a few months after the initiation of infliximab infusions for psoriasis.
DISCUSSION: Immunosuppresion is related to HPV/MC flares. Biological therapy and in particular infliximab treatment acts by immunomodulation and eventually a degree of immunosuppression.
CONCLUSIONS: Anti-TNF treatment could be associated with HPV and/or MC flares. For this reason, we suggest the consideration of obtaining a routine cervical PAP smear before the commencement and during treatment with anti-TNF agents for psoriasis.
PMID: 22559024 [PubMed - in process]
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